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Multiple Haemophilus influenzae strains and strain variants
coexist in the respiratory tract of patients with cystic fibrosis.
Autor – Moller LV; Regelink
AG; Grasselier H; Dankert-Roelse JE; Dankert J; van Alphen L
Zeitschrift/Erscheinungsdatum –
J Infect Dis 1995 Nov;172(5):1388-92.
STUDY OBJECTIVES:
To investigate the epidemiology of nontypeable Haemophilus influenzae
in the respiratory tract of cystic fibrosis (CF) patients, H. influenzae
isolates from sputum specimens of 40 CF patients were analyzed longitudinally
for 2 years. The isolates were characterized by analysis of the major
outer membrane protein (MOMP) patterns. MOMP variant H. influenzae strains
were discriminated from distinct strains by randomly amplified polymorphic
DNA analysis of genomic DNA. Multiple H. influenzae strains and MOMP variant
strains were isolated from single sputum specimens of 29 patients. In
22 patients, a distinct H. influenzae strain persisted over time (median
persistence, 8 months; range 2-24). In general, the appearance of MOMP
variant strains did not coincide with the occurrence of exacerbations.
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